When Red is encountered in Mt. Silver during Generation II, he has no speech, merely repeating an ellipsis before beginning the battle. This is a reference to the fact that during Generation I he is a silent protagonist, answering only "yes" or "no" questions. He also remains silent when confronted in later generations.
In FireRed and LeafGreen, Blue sarcastically calls him a chatty gossip.
Plus, Red isn't in the Anime.
While Red himself does not appear in the anime, his counterpart, introduced in the first episode, is the anime's main character, Ash Ketchum. Like Red, Ash is from Pallet Town, on a journey to become a Pokémon Master. Unlike Red, Ash's journey did not end with Kanto, and Ash has continued through every other region introduced in the main series games, as well as the Orange Archipelago south of Kanto, taking the place of the player characters of Generation II during Johto, and being joined by the anime counterparts of May and Dawn during the Hoenn and Sinnoh sagas. Instead of starting with one of the standard three Kanto starters, however, Ash began his journey with a Pikachu, inspiring Pokémon Yellow's creation, as well as causing some to consider Red and Ash to be the same person, most especially due to Red owning one as well.