Question

I heard somewhere that Mewtwo is the hardest Pokemon to catch. Is this true or was it just something from the anime?

Answer 1

No, it has a catch rate of 3 which it shares with other Pokemon. So technically they are all the hardest to catch.

Source

Comments

This is true ...i have catch it many times but only with low hp and ultra ball

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You could also say the ones that flee instantly are even harder to catch.

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ive played heartgold and soulsilver and every time i went to catch him i just threw an ultra ball after i lowered his hp and caught right away....just luck i suppose