All of Mew's stats are base 100 which makes him good for EV training.
http://pokemondb.net/pokedex/mew
Mewtwo is better for a Special Sweeper with a higher SpAtk.
http://pokemondb.net/pokedex/mewtwo
So Mewtwo is better if you're not into EV training.
They both have the same weaknesses although they have different abilities. Movesets are available through the links.
If this didn't answer your question then comment and I'll fix it up.