PokéBase - Pokémon Q&A
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Will it have the opposite effect or no?

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You mean hurt the user more?
Yes.

>Liquid Ooze causes HP-draining moves to cause injury. If a Pokémon with Liquid Ooze is hit by an HP-draining move such as Leech Life or Giga Drain, the amount of HP that should be recovered by the opponent will be dealt as damage instead. However, Liquid Ooze does not prevent damage to the Pokémon.

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