EVs: 252 Defense, 252 S.Defense, 6 Hp
Substitute or Toxic
This is an anti-stat booster set, as everyone knows stat boosters can be exceedingly frustrating but Mandibuzz can take care of that. Whirlwind blows the Pokemon and it's boosts away. Roost is for healing. Substitute prevents the foe from hurting you which is very useful, but if you do not have Toxic-spikes support on your team Toxic can be useful. Punishment is there not only there for STAB and so Taunt does not ruin you, but because it hits hard on Stat boosters with an extra +20 base-power per boost starting at 60 Base-power.
Use with Entry hazard support for Maximum effectiveness.