Let us say I have Toxic Spiked the opponent (never going to happen...) and they switch to Conkeldurr w/ Guts.
What happens?
Conkeldurr would be Poisoned first. Flame Orb would not activate unless the Poison status is cleared while Conkeldurr is on the field, or if T-Spikes are gone and Conk is healed.
