Neither Unseen Fist nor Wicked Blow has anything to do with ignoring Substitute. However, one of the benefits of Surging Strikes (the Rapid Strike signature move) as compared to Wicked Blow (the Single Strike move) is that if the opponent does have a substitute, it might break on the first hit and then you still have 2 hits left to deal damage to the regular health bar, instead of allowing the substitute to sop up the entire move.