*Crystal* in particular will not run in any meaningful sense on an original Game Boy. While Gold and Silver still used the DMG-style cartridges, which have a notch in the corner and a "Nintendo Game Boy" oval that dents inward, Crystal's cartridge is full-on GBC with no notch and an outward indent. This means, among other things, that the cartridge won't fit in the original Game Boy's slot, and because the notch is designed for that model's power switch to slide into, you couldn't turn the system on even if it did fit.
If you decided to repackage the game in a form that did fit (or if you tried to play it in the Super Game Boy accessory for SNES, which has no power switch slider), you would get an error message on boot that says this game is only for GBC.
You do have the option of using N64 with Stadium 2's Game Boy Tower to play Crystal just fine (though someone who's asking this probably doesn't have these things, and it's far from necessary just to be able to play Crystal), or on GameCube through the Game Boy Player.
