Playing a ROM of a Pokemon game typically is the same as playing the real game, unless you’re playing a ROM hack.
However, playing a a ROM means you may also encounter unexpected or unexplained behaviour in the game. Some I’ve notice from reports here over the years may include:
- random freezing
- Save issues
- Corruption
- Graphical errors in display
- Piracy locks (less common to experience nowadays)
- TID/PID changes randomly (only saw this reported in here twice)
- issues with time-based events
Please note that this is not a comprehensive list of issues and may or may not happen when playing a ROM.