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Lets say you use Safeguard and then Thrash. Will you become confused?

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Safeguard prevents the user and its party from being affected by any status condition for five turns except those caused by special abilities, held items or self-inflicted statuses.

So no, safeguard does not protect your Pokemon against self-inflicted status.
Source: http://bulbapedia.bulbagarden.net/wiki/Safeguard

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Dang my typing skills are terrible.
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No, it does not.
>It does not prevent self-inflicted status such as that from Toxic Orb, or the confusion side-effect of Outrage. -Smogon

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Safeguard prevents the user and its party from being affected by any status condition for five turns except those caused by special abilities, held items or self-inflicted statuses.

So yes, it will become confused.

Source

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