PokéBase - Pokémon Q&A
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http://www.smogon.com/bw/pokemon/scrafty

This states the best three items to give a Scrafty are the Leftovers, Life Orb, and Lum Berry. It really depends on your Moveset though, as shown in the link.

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My moveset for Scrafty consists of: -Drain Punch -Ice Punch -Crunch -Bulk Up.
Yeah, a Bulk Up Moveset uses Lefties always.
Thanks Mike!