This is an interesting point you bring up...
I think that this very plausible. Like you mentioned, Unova is urban-themed, and Kalos is based around aesthetic appeal .
Sinnoh has kind of rugged, and untamed feel to it, and is reflected in it's Pokemon. (lot's of variety of life, the Space-Time continuum, fewer fire types hence it's colder, and wetter climate...
Hoenn feels like a region ravaged by conflict, demonstrated in it's hostile looking, and powerful Pokemon. It's legendaries, and evil teams also reflect this...
Johto has a laid back aura to it, also shown in it's Pokemon, and geography.(It's Pokemon all seem to have some obvious degree of happiness shown, or are seem carefree, save for a few.
It's legendaries are also not in conflict, though rivals, they keep order throughout the land.
It's geography is also very calm, and has many fields and forests
Kanto...... This was the first region, so it's theme may be neutrality. It has a little bit of everything, and is very balanced.