Theoretically, you could abuse Moody, Normal STAB and Boomburst's great base power. Unfortunately, Smeargle's ability to abuse Boomburst is stymied by the fact that Moody is banned in most Smogon tiers, and Smeargle's abysmal 20 Special Attack. Besides, Smeargle has better things to do like Spore or Defog or whatever Smeargle does these days.
Realistically, you're much better off using a utility move like Fake Out. While Boomburst is cool on paper, Smeargle's pathetic offences negate any usefulness you might get from the move.