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I've looked on almost every website and I couldn't find anything on the person who created the DNA Splicers. They appear to be a piece of technology so it had to be made by someone but I couldn't find any information from the games, anime, or manga.


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Nothing goes into details, but Drayden does mention something in the Unova games:

And there may be proof of this to be found in a treasure passed down in my family for generations: the DNA Splicers.

This implies that Drayden's ancestors created the DNA Splicers, long ago.


Hope I helped!

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Actually, the dna splicers are part of kyurem. In the cutscenes in b2w2, you can see it making the point at the top of kyurems head and in his official art it is always there
The evidence stands that someone had to have created them at one point or another.