Yes there is. If you save in the streets of Lumiose City your entire game can freeze and you need to delete the save file and start over again. If you save in buildings you will be fine. I think I read somewhere it is to do with the camera angles for something.
Here is a source for it.
With the release of Version 1.1, this glitch has been fixed and it is now safe to save in Lumiose City.
Source
