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>Inflicts damage equal to the user's remaining HP. User faints. ~ Pokémon DB

If I use, say, Final Gambit Staraptor vs. Focus Sash Breloom, and Breloom has less HP than Staraptor, will Final Gambit OHKO through the Focus Sash?

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No, it will not. Final Gambit can still trigger the Target's Focus Sash, Focus Band, Sturdy, or if the target has used Endure, it will endure the hit.

Source: http://bulbapedia.bulbagarden.net/wiki/Final_Gambit_(move)

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