I read this question, which got me thinking. If a set of four types has no weaknesses, that means that for every two-type subset, its weaknesses are all resisted by the other two types. In case you're dying to know and too lazy to click on the link, the combinations are water ground flying steel and water bug steel dragon. This could be useful for building defensive cores, as they're supposed to consist of two Pokemon that are each able to switch into attacks that threaten the other. I chose sets of two Pokemon that are both viable in the same Smogon tier. There might actually be more such cores, because these weaknesses were calculated without considering abilities. Which of these might actually work?
Set in Uber (not technically a tier, but this post uses "tier" and "format" interchangeably)
Palkia @ Life Orb
Ability: Pressure
EVs: 4 Def / 252 SpA / 252 Spe
Timid Nature
-Surf
-Spatial Rend
-Thunderbolt
-Ice Beam
Genesect @ Choice Scarf
Ability: Download
EVs: 252 Atk / 4 Def / 252 Spe
Adamant Nature (hasty if adamant is impossible)
-U-Turn
-Iron Head
-Extreme Speed
-Blaze Kick
Set in UU
Empoleon @ Life Orb
Ability: Torrent
EVs: 4 Def / 252 SpA / 252 Spe
Modest Nature
-Agility
-Surf
-Flash Cannon
-Grass Knot
Gligar @ Eviolite
Ability: Immunity
EVs: 252 HP / 4 Def / 252 SpD
Careful Nature
-U-Turn
-Earthquake
-Roost
-Toxic
Set in NU
Steelix @ Leftovers
Ability: Sturdy
EVs: 252 HP / 4 Atk / 252 SpD
Sassy Nature
IVs: 0 Spe
-Curse
-Gyro Ball
-Earthquake
-Rock Slide
Mantine @ Leftovers
Ability: Water Absorb
EVs: 252 HP / 252 Def / 4 SpD
Bold Nature
-Toxic
-Scald
-Air Slash
-Protect