PokéBase - Pokémon Q&A
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I mean if you knock it out or run away, you could make it respawn somehow.

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Starting in Generation III, if the player runs from a Legendary Pokémon, the Pokémon reappears when the player leaves and re-enters its location,
Starting in Pokémon Platinum, if the player defeats or runs from an in-game event Pokémon, then it reappears next time the player enters the Hall of Fame.

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This means you have one chance to catch legendaries in gen 2, and you can catch legendaries in gen 3 and DP if you ran from them before.

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Ah okay. Thanks.