It could work, yes. And that strategy pretty much already exists. It is simply called Baton Pass.
However with those items, no, no it won't work. One hit and Smeargle is dead. So it would be advisable to slap on a Focus Sash > Quick Claw, Leftovers and run the standard Ev spread over that one, since the standard one works much betterL 96 HP / 120 Def / 40 SDef / 252 Spe.
It would also be optimized by running Shell Smash over Dragon Dance, which makes you a sweeper from turn one and does the job of 2 DDs in one turn.
Changing its Mamoswine's item is also highly recommended so that it can actually sweep, because there will usually be a Pokemon to resists one of its move and just KO it ending its sweep. I would suggest running more speed and a little less HP. 132 Speed EVs will enable it to outpace everything up to Scarfed Garchomp at +2. Change its item to Focus Sash or Life Orb to unsure that you kill a few Pokemon, even at your boost, nothing is unsured.
Having a few other Pokemon with the ability to pass boosts is also an option to help ot sweep better.