A good power of alchemy strategy would be to have whimsicott (with prankster) and muk In a double battle. Whimsicott uses memento, giving muk prankster. Then, you can go first using minimize, and any other status move. And with minimize, you can set up a lot. Mabye bring in a Pokémon that covers his weakness (ground).
Another good strategy could be Muk with an azurill(with huge power). First turn, it is quite likely that they will knock out the azurill, so Muk can just set up curse or minimize or attack or something. When Muk gets huge power, it has a MASSIVE attack stat. Bring in a ghost type Pokémon so you can explode using explosion whenever you feel like taking out their Pokémon.
Another good strategy would be to have its teammate be a swoobat with simple. First turn, it might be a good idea to try and knock out the swoobat with a dark move, or if you are confident that it will be killed, just use minimize or curse or attack or something. When muk gets simple, it can use curse, acid armor, or minimize and get twice the boost. That makes it so that it can sweep easily and evade attacks really well with minimize boost