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Which nature is better for mewtwo y

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Both are pretty bad, but Jolly is better
What game are you asking about? What do you want to do with a Mewtwo? Do you battle other people, in-game trainers, or something else?
Both are really really bad. You wouldn't want to have an SpA depleting nature on a Special Attacker.

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Both are bad, you are asking which is better so I would say Jolly.
Impish increases defence and lowers special attack, Jolly increases speed and lowers special attack. Since mewtwo is a fast offensive Pokemon you would want Jolly.

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