Ability:Pressure or Frisk?
-Substitute or Protect?
-Rest or Pain Split?
-Toxic or Curse?
-Sleep talk, Seismis toss, or Shadow sneak?
Well, the Smogon sample set says to use Toxic, Seismic Toss, Rest, and Sleep Talk. So I would say don't use Substitute or Protect, and instead use Sleep Talk.
If you must decide between Substitute and Protect, I would go for Substitute, as it has the possibility of lasting more than a turn.
Hope I helped!