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Specifically how viable is Self-Destruct on a Special Attacking Mewtwo in Gen 4, and a Physical attacker Mewtwo in Gen 8

This is for singles Ubers battles

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It's a good idea.
Imagine a  random PS! Player:
Oh! Finally powerful Mewtwo is about to go down. What!? It is exploding?!
It's okay for both gen 4 special and gen 8 physical. Execept , special Mewtwo is better than physical one in base s.atk and atk stat respectively. But still it's totally your choice.
Hope I helped!
But like, in Gen 4 is it worth the move slot for Explosion, and would a special Mewtwo still deal a lot of damage with it?
Compared to it's 110 Atk, It's 154 SpA is much better, and from STAB Psychic, it's even better. Although Self-Destruct is quite powerful, but Mewtwo is quite a hard-hitting uber mon in gen 4. Is also one of the fastest.
Some mega-gengar also carry explosion to explode at low health
No, they carry Destiny Bond.
Lmao Mega-Gengar with explosion would be funny. Maybe Gen 4 Gengar would be understandable because of how broken Explosion was back then but a Gen 6 or 7 Gengar running Explosion would be awesome to see.
Destiny Bond is a popular trick for ghost type Pokemons but it can often fail. Although why would anyone use physical Gengar? Sepf Destruct has 50 less power than Explosion and Gengar's attack is 65 ONLY.

1 Answer

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Self-destruct Mewtwo is viable in gen 4. Here's a moveset you can copy.

Mewtwo @ life orb
EVs: 4 Atk / 252 SpA / 252 Spe
Naive nature
- ice beam
- aura sphere
- fire blast
- self-destruct

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However, it's not good in gen 8 because self-destruct was nerfed to do about half the damage that it used to. Self-destruct is so weak that it sometimes does less damage than attacks with no negative effects.

4 Atk Life Orb Mewtwo Self-Destruct vs. 0 HP / 4 Def Kyogre: 221-260 (64.8 - 76.2%) -- guaranteed 2HKO
252 SpA Life Orb Mewtwo Psystrike vs. 0 HP / 4 Def Kyogre: 263-309 (77.1 - 90.6%) -- guaranteed 2HKO

Additionally, now that shadow Calyrex exists, all Mewtwo sets are probably outclassed by shadow Calyrex.
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