What are some things to be wary of in a Pokemon Yellow Nuzlocke?

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Make getting Bulbasaur a priority if you can. It’s the best starter, being good against Brock, Misty, and Giovanni, and resisting Lt. Surge, Erika, and Bruno.
For that matter, you should try to get all three starters. All are formidable, and all can deal with a fair few enemies in-game.
Snorlax and Lapras are also amazing, and you get them as the story progresses. Try to catch Snorlax and receive Lapras -- you don’t need to rely heavily on luck, and they’re great assets to a team (you may not want Blastoise if you grab the Lapras).
Hitmonlee is pretty solid after you get it from the Fighting Dojo. It murders once it gets Jump Kick/ Hi Jump Kick, plus it gets Strength for additional damage. Do note that depending on your ruleset, you may not be able to get both Lapras and Hitmonlee.
In terms of wild Pokémon, Kadabra is great if you can manage to snag an Abra. Raticate is surprisingly solid as well (at least in the early game), as it can learn Hyper Fang at an incredibly low level and Super Fang a bit later.
Nidoking can be obtained early, with Nidoran and the Moon Stone being found before exiting Mt. Moon. It learns the excellent Thrash at Level 23, which absolutely tears through foes.

SelfDestruct and Explosion are deadly. You should always be prepared when going up against a member of the Geodude/Voltorb family, as they can end a team member’s life in an instant.
Be very, very careful in the Saffron Gym. Sabrina (and all other Psychic users) are deadly and can be tough to beat. Use Pokemon with solid physical attacks, as the Abra family is quite weak on the physical side. Snorlax is fairly well-suited for the job, with powerful STAB in Body Slam and a fairly okay Special stat.
If you don’t manage to get a Mankey or Nidoran before Brock, you’ll have a very tough time. Try to get one, and if you can’t, pray to whatever god you happen to believe in (or even the fabled RNGesus) that you somehow pull out a victory.

Always, always have healing items. Being careless can lead to an avoidable death, so try to always pack something to quickly regenerate your Pokemons’ health. Remember that poison hurts you in the overworld, so be sure that it doesn’t claim a victim.
I cannot emphasise enough how much of a killer poison is in the early game. Don't be afraid to purchase Antidotes, which are cheap and will almost certainly save you when going through Viridian Forest.
Critical hits are different in Gen I, and you can easily be hit by an errant one if you aren’t careful. Always assume every attack will be a crit, and if your Pokémon would be KOed by a crit, switch out. The risk isn’t often worth it.
If you don’t have a full team for whatever reason, you can try fishing up some fodder in towns that can be used as sacrifices in battle if things get dire. Alternatively, you can make them into powerful team members.
As TMs aren’t reusable, be sure to give those one-time finds to very strong Pokémon, or those that will be in your final team, just before the Elite 4. This lowers the risk of them dying and you losing the TM forever.

Best of luck to you on your Nuzlocke!

answered Apr 14, 2021 by Amethyst
selected Apr 14, 2021 by PeeKayFreeze