PokéBase - Pokémon Q&A
5 votes

If you have a good competitive moveset for Mewtwo, post an answer below and upvote the best ones. Movesets for any of its pre-evolutions can also be shared on this thread.

Be sure to include full set details in your post, e.g. items, abilties, natures and EVs. Some detail, including the intended game mode for your set, is also appreciated. Access the full list of guidelines here.

Mewtwo Pokédex and learnset for reference.


edited by
Some of the move sets are different. (Mine!)

FYI, it's the one with the massive images of the Mega forms of Mewtwo.
Mewtwo @ Leftovers
Nature: Modest
EVs: 252 HP 252 Spattack/ 6 Sp Def
Ability: Pressure
Calm Mind
Aura Sphere
Psystrike: STAB, takes care of Fighting and Poison
Calm Mind: A move to just set up
Shadow Ball: To take care of Psychic and Ghost types
Aura Sphere: For Dark type Coverage
Mewtwo with mewtwonite y
Fire Blast
Ice Beam
Mewtwo with calm mind can sweep.
And bulk up/ swords dance

42 Answers

–2 votes

My Mewtwo's moveset in Fire Red:
Works great for Ice and Steel types (Steel resists so many types). Strong move with burning possibility and high PP and I have made it even higher.
For Flying, Ground and Dragon types but also for rival's Tyranitar because it resists all the other moves.
Basically for Psychic and Ghost types but also a good non-Special Attack move for good Special Defenders.
Of course. Mewtwo's Psychic. Try to name more iconic duo. This STAB move exterminates everything so I had to boost its PP to the max just like Flamethrower's.

With these moves you dominate the Pokémon world and easily humiliate elite four (even the 2nd round) by destroying every single Pokémon by one hit (except for Tyranitar which needs two Ice Beams).

With my 100 level Mewtwo with this moves I can easily level up weaker Pokémon with Exp. Share and just walk over the opponents to the Hall of Fame as many times as I want. It doesn't require any healing items.

–4 votes

MEW V.II(Mewtwo)@Leftovers/Mewtwonite X
Ability: Pressure/Steadfast
EVs: 3 Sp. Atk
Impish Nature (+Def, -Sp.Atk)

  • Psystrike: Obivously, Sig, Great Atk and Acc, Inflicts Atk based on Def, not Sp.Def. Coverage vs Fighting and Poison
  • Aura Sphere: Good Atk, Perfect Acc, coverage vs Normal, Ice, Rock, Dark, and Steel
  • Shadow Ball: Good Atk, Great Acc, chance to lower Sp.Def, coverage vs Ghost and Dark
  • Fire Blast: Great Atk, Good Acc, chance to burn, coverage vs Grass, Ice, Bug, and Steel
This set is all wrong:

3 Sp.Atk EV's will not raise it's Sp.Atk even by 1.
Impish is a terrible Nature for Mewtwo.
Why have the Mewtwonite X if you're a Special Attacker?

Were you just trying to troll or something?
This is quite obviously an attempt to troll. Nevertheless, quite a bad one. Try again next time.
This is beautiful I love it
You still have 249 EVs leftover to use. :L
I suggest Timid Nature if going down that Special Sweeper path.