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I want to know if there are any Pokemon that my Mewtwo's attacks are effective against that can stand more than 3 hits. (Basically can my Mewtwo 2HKO anything as long as its attacks are effective).

You can include held items and how threatening they are:

Mewtwo (From Kanto)
Ability: Unerve
Nature: Modest
IVs+EVs: 31, 252

Moves: Shadow ball, Aura Sphere, Ice beam and flamethrower.

Held item: Life orb

Also does anyone know if theres an item that will make my attacks stronger? Right now life orb is best I think.

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Whaaaaasa... yeah okay.
Mega Gyarados is the best. D-dance Waterfall Earthquake and Crunch. Also lowest the opponents attack  and allows you to take a not very effective attack if you mega evolve properly.
Mega Salamence also gets Intimidate as a pre-mega ability, but has better stats and gets Aerilate.
But mega Gyarados is unpredictable.
What format?

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252+ SpA Life Orb Mewtwo Aura Sphere vs. 248 HP / 8 SpD Eviolite Chansey: 179-213 (25.4 - 30.2%) -- guaranteed 4HKO

No, Eviolite Chansey, as well as many other Pokemon, take at least 3 hits to be KOed from the set you gave.

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