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## Long wave run-up on plane and “non-reflecting” slopes

The long wave run-up on two types of slopes is investigated numerically within the

framework of nonlinear shallow water theory using the CLAWPACK software. One of the slopes

represents a plane slope widely used in the laboratory and numerical experiments; the second is the

so-called “non-reflecting” slope (h ∼ x4/3, where h is the basin depth and x is the distance from

the shoreline). In the case of very low wave amplitudes when there is no wave breaking, the run-up

height is greater on the non-reflecting beach than that on the plane slope. As the wave amplitude

increases, the breaking effects have the stronger impact in the case of non-reflecting beach and the

run-up height becomes smaller.

Run-up of long waves on a beach consisting of three pieces of constant but different slopes is studied. Linear shallow-water theory is used for incoming impulse evolution, and nonlinear corrections are obtained for the run-up stage. It is demonstrated that bottom profile influences the run-up characteristics and can lead to resonance effects: increase of wave height, particle velocity, and number of oscillations. Simple parameterization of tsunami source through an earthquake magnitude is used to calculate the run-up height versus earthquake magnitude. It is shown that resonance effects lead to the sufficient increase of run-up heights for the weakest earthquakes, and a tsunami wave does not break on chosen bottom relief if the earthquake magnitude does not exceed 7.8.

Nonlinear wave run-up on the beach caused by a harmonic wave maker located at some distance from the shore line is studied experimentally. It is revealed that under certain wave excitation frequencies, a significant increase in run-up amplification is observed. It is found that this amplification is due to the excitation of resonant mode in the region between the shoreline and wave maker. Frequency and magnitude of the maximum amplification are in good correlation with the numerical calculation results represented in the paper (Stefanakis et al., 2011). These effects are very important for understanding the nature of rogue waves in the coastal zone.

We present an exact analytical solution of the nonlinear shallow water theory for wave run-up in inclined channels of arbitrary cross-section, which generalizes previous studies on wave run-up for a plane beach and channels of parabolic cross-section. The solution is found using a hodograph-type transform, which extends the well-known Carrier–Greenspan transform for wave run-up on a plane beach. As a result, the nonlinear shallow water equations are reduced to a single one-dimensional linear wave equation for an auxiliary function and all physical variables can be expressed in terms of this function by purely algebraic formulas. In the special case of a U-shaped channel this equation coincides with a spherically symmetric wave equation in space, whose dimension is defined by the channel cross-section and can be fractional. As an example, the run-up of a sinusoidal wave on a beach is considered for channels of several different cross-sections and the influence of the cross-section on wave run-up characteristics is studied

One of the key advances in genome assembly that has led to a significant improvement in contig lengths has been improved algorithms for utilization of paired reads (mate-pairs). While in most assemblers, mate-pair information is used in a post-processing step, the recently proposed Paired de Bruijn Graph (PDBG) approach incorporates the mate-pair information directly in the assembly graph structure. However, the PDBG approach faces difficulties when the variation in the insert sizes is high. To address this problem, we first transform mate-pairs into edge-pair histograms that allow one to better estimate the distance between edges in the assembly graph that represent regions linked by multiple mate-pairs. Further, we combine the ideas of mate-pair transformation and PDBGs to construct new data structures for genome assembly: pathsets and pathset graphs.

Papers about natural protection territories

Many environmental stimuli present a quasi-rhythmic structure at different timescales that the brain needs to decompose and integrate. Cortical oscillations have been proposed as instruments of sensory de-multiplexing, i.e., the parallel processing of different frequency streams in sensory signals. Yet their causal role in such a process has never been demonstrated. Here, we used a neural microcircuit model to address whether coupled theta–gamma oscillations, as observed in human auditory cortex, could underpin the multiscale sensory analysis of speech. We show that, in continuous speech, theta oscillations can flexibly track the syllabic rhythm and temporally organize the phoneme-level response of gamma neurons into a code that enables syllable identification. The tracking of slow speech fluctuations by theta oscillations, and its coupling to gamma-spiking activity both appeared as critical features for accurate speech encoding. These results demonstrate that cortical oscillations can be a key instrument of speech de-multiplexing, parsing, and encoding.

Neuronal nicotinic acetylcholine receptors (NNRs) of the α7 subtype have been shown to contribute to the release of dopamine in the nucleus accumbens. The site of action and the underlying mechanism, however, are unclear. Here we applied a circuit modeling approach, supported by electrochemical in vivo recordings, to clarify this issue. Modeling revealed two potential mechanisms for the drop in accumbal dopamine efflux evoked by the selective α7 partial agonist TC-7020. TC-7020 could desensitize α7 NNRs located predominantly on dopamine neurons or glutamatergic afferents to them or, alternatively, activate α7 NNRs located on the glutamatergic afferents to GABAergic interneurons in the ventral tegmental area. Only the model based on desensitization, however, was able to explain the neutralizing effect of coapplied PNU-120596, a positive allosteric modulator. According to our results, the most likely sites of action are the preterminal α7 NNRs controlling glutamate release from cortical afferents to the nucleus accumbens. These findings offer a rationale for the further investigation of α7 NNR agonists as therapy for diseases associated with enhanced mesolimbic dopaminergic tone, such as schizophrenia and addiction

Let k be a field of characteristic zero, let G be a connected reductive algebraic group over k and let g be its Lie algebra. Let k(G), respectively, k(g), be the field of k- rational functions on G, respectively, g. The conjugation action of G on itself induces the adjoint action of G on g. We investigate the question whether or not the field extensions k(G)/k(G)^G and k(g)/k(g)^G are purely transcendental. We show that the answer is the same for k(G)/k(G)^G and k(g)/k(g)^G, and reduce the problem to the case where G is simple. For simple groups we show that the answer is positive if G is split of type A_n or C_n, and negative for groups of other types, except possibly G_2. A key ingredient in the proof of the negative result is a recent formula for the unramified Brauer group of a homogeneous space with connected stabilizers. As a byproduct of our investigation we give an affirmative answer to a question of Grothendieck about the existence of a rational section of the categorical quotient morphism for the conjugating action of G on itself.

Let G be a connected semisimple algebraic group over an algebraically closed field k. In 1965 Steinberg proved that if G is simply connected, then in G there exists a closed irreducible cross-section of the set of closures of regular conjugacy classes. We prove that in arbitrary G such a cross-section exists if and only if the universal covering isogeny Ĝ → G is bijective; this answers Grothendieck's question cited in the epigraph. In particular, for char k = 0, the converse to Steinberg's theorem holds. The existence of a cross-section in G implies, at least for char k = 0, that the algebra k[G]G of class functions on G is generated by rk G elements. We describe, for arbitrary G, a minimal generating set of k[G]G and that of the representation ring of G and answer two Grothendieck's questions on constructing generating sets of k[G]G. We prove the existence of a rational (i.e., local) section of the quotient morphism for arbitrary G and the existence of a rational cross-section in G (for char k = 0, this has been proved earlier); this answers the other question cited in the epigraph. We also prove that the existence of a rational section is equivalent to the existence of a rational W-equivariant map T- - - >G/T where T is a maximal torus of G and W the Weyl group.