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If you have a good competitive moveset for Mewtwo, post an answer below and upvote the best ones.

Be sure to include full set details in your post, e.g. items, abilities, natures and EVs. Some detail, including the intended game mode for your set, is also appreciated. Access the full list of guidelines here.

Mewtwo Pokédex and learnset for reference.

Sprite

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23 Answers

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PHYSICAL SWEEPER MEGA MEWTWO X

Mewtwo is one of the original Ubers of Pokemon, being a gen 1 Pokemon, and being in Ubers since the dawn of Pokemon. Why? Mewtwo, is an extremely versatile Pokemon, and has amazing stats. With the Mega Stones, introduced in Pokemon X and Y, as Mewtwonite X and Y, further reason for it's justification in Ubers. I run Both Mega Mewtwo X AND Y. Mega Mewtwo has one of the best Attack stats in all of Pokemon, and that is what I will be focusing on. Mega Mewtwo X is weak to Ghost, Fairy, and Flying Moves. It isn't weak to Dark, as it is part Fighting. This Mega Pokemon is very versatile, and can be a mixed, special (not advised), or physical sweeper.

This is the move set I am satisfied with, and currently use on my Pokemon X Battle Box Team...

DATA

Mewtwo @ Mewtwonie X
Ability: Pressure
EVs: 252 Atk / 4 SpD / 252 Spe
Jolly Nature
- Drain Punch
- Ice Punch
- Psycho Cut
- Poison Jab

MOVES

  • Drain Punch, To regain HP and Counter Dark type Ubers, like Darkrai, which is extremely common in Gen 6 Ubers. Due to Mega Mewtwo X being Psychic - Fighting, Drain Punch gets STAB.

  • Ice Punch, for type coverage, and countering Flying types. Oddly enough, it freezes Pokemon often enough to help me win.

  • Psycho Cut, STAB, and Crit chance. I use this over Zen Headbutt, as it has good Accuracy, but Zen Headbutt has flinch chance.

  • Poison Jab To counter pesky Geomancy Xerneas with Power Herb, a common pest in Ubers. Poison Jab also has 30% Poisoning chance.

USEFUL SUBSTITUTE MOVES
Stone Edge, Zen Headbutt, Aqua Tail, Fire Punch, Thunder Punch, Earthquake, Rock Slide, Bulk Up, Aerial Ace.

Remember that Mewtwo in general is an extremely versatile Pokemon.

I wish that Mewtwo got a physical Dark or Ghost move. Foul Play isn't useful. I wish it got Knock Off, which is actually useful.

Mewtwo is one of the best sweepers ever :)

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Gen 7 Ubers / National Dex AG


Mewtwo-Mega-X @ Mewtwonite X
Ability: Unnerve
EVs: 252 Atk / 4 SpD / 252 Spe
Jolly / Hasty / Naive Nature
- Low Kick / Drain Punch
- Bulk Up
- Ice Beam
- Stone Edge

STAB Low Kick hits the many heavy Pokemon in Ubers/Nat Dex AG hard. Drain Punch can be used instead, as it can heal you, which pairs nicely with Bulk Up. Bulk Up Mewtwo's physical moves and makes it harder to KO by physical moves. Ice Beam seems like a weird choice on a Pokemon with 194 Attack and Bulk Up, however it lets Mewtwo get rid of Mega Salamence, which uses Intimidate as its pre-mega ability, and Zygarde, which has Coil and great physical bulk. Stone Edge kills Ho-oh and can overwhelm the niche Lugia. Just watch out for that 80% accuracy.

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Let's Go

Mewtwo
Timid Nature
- Psychic
- Flamethrower
- Calm Mind
- Shadow Ball

Psychic for the stab. flamethrower for bug coverage. shadow ball is used over earthquake for the ghost types because mewtwo has higher special attack. calm mind for the sweeping.

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