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9 votes
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If you have a good competitive moveset for Mewtwo, post an answer below and upvote the best ones.

Be sure to include full set details in your post, e.g. items, abilities, natures and EVs. Some detail, including the intended game mode for your set, is also appreciated. Access the full list of guidelines here.

Mewtwo Pokédex and learnset for reference.

Sprite

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Ha, just realized almost all of these sets are almost the same.
Some of the move sets are different. (Mine!)

FYI, it's the one with the massive images of the Mega forms of Mewtwo.
Mewtwo with calm mind can sweep.
And bulk up/ swords dance

39 Answers

6 votes

Gen V

Mewtwo @ Choice Specs
Ability: Pressure
EVs: 4 HP / 252 SpA / 252 Spd
Timid Nature
- Aura Sphere
- Thunder
- Shadow Ball
- Ice Beam

This provides Super-Effective coverage against almost anything you'd face in Ubers. Shadow Ball deals with all the Psychics, as well as Chandelure. Thunder takes down the Flying types of Uber, as well as Kyogre. Ice Beam also deals with the Flying types of Uber, all the Dragon types, and Groudon. Aura Sphere takes down Dialga and Darkrai. The only common Ubers who won't be hit for super-effective damage are Jirachi, some random Arceus types, and Palkia. However, you'll be able to do enough damage to these Pokemon with a neutral hit off of Mewtwo's Choice Specs boosted Special Attack. Your EVs are sweeping EVs.

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My Mewtwo has timid nature. It's not that bad.
go with thunderbolt, just sayin'
*cough* Pystrike *cough*
This is a good set, but the problem is that without the mewtwo x stone, none of these attacks get STAB.
Why no Psystrike or Psychic for stab?
thunder isnt accurate, if you wanted an electric type move on mewtwo, go thunderbolt
3 votes

Mewtwo @ Life Orb
Ability: Pressure
EVs: 4 HP / 252 SpA / 252 Spd
Timid Nature
- Psystrike
- Aura Sphere
- Ice Beam
- Calm Mind

Psystrike is for going Physical, it's Mewtwo's signature move so it's awesome.
Aura Sphere gives coverage against Darkrai, mainly.
Ice Beam hits super effective against annoying dragons.
Calm Mind to get a nice boost in Special Attack and Special Defense.

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Some people think shadow ball is Mewtwo's signature move.
It isn't. Those people are retards.
I can understand why they would though. In one of the first movies; "Mewtwo vs. Mew", Mewtwo kept on using shadow ball against mew. But it looked nothing like in the games.
I like how Mewtwo is so boss and mew is so cute
Also, in Pokemon GO mewtwo has three legacy charged moves: Psystrike, Shadow Ball, and Hyper Beam. Hyper beam is on a bunch of other pokemon, and shadow ball came before Psystrike in Pokemon GO.
3 votes

Role: Sunny Sweeper

Mewtwo @ Life Orb
Ability: Pressure
Timid Nature
EVs: 4 HP / 252 SpA / 252 Spd
- Solar Beam
- Flamethrower
- Aura Sphere
- Psystrike


When you have a Groudon lead.
Solar Beam is 1 turn coverage in the sun, along with Flamethrower getting powered up. Aura Sphere is coverage, while Psystrike is amazing STAB.

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The problem with relying on that groudon lead, is rayquaza or kyogre could easily mess that up.
mewtwo in general isnt a good poke to be on a sun team
3 votes

Mewtwo @ Leftovers
Ability: Pressure
Jolly Nature
EVs: 252 Atk / 252 Spe / 6 HP
- Bulk Up
- Ice Punch
- Fire Punch / Thunder Punch
- Earthquake / Drain Punch


Ever notice that great 110 Attack? Probably not as Mewtwo has the second highest Special Attack in the game (154), but his Attack is still great. Bulk Up is boosting. Ice Punch is coverage. Fire Punch/Thunder Punch choose coverage. Earthquake/Drain Punch more powerful coverage or weaker coverage and healing.

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Who voted this down? Nothing wrong, is there?
Ugh, Psystrike is the only viable Physical hitting move.
Having a Psychic type, let alone the strongest Psychic type in the game, that doesn't know a single Psychic move? No thank you. The only time I'd bother with a physical move for Mewtwo is Brick Break and only until I learn Aura Sphere.

Not to mention, that Mewtwo's special attack is 40% higher.  And since Flamethrower/Thunderbolt/Ice beam are all 26.6% stronger than their punch counterparts, they'd be 77.3% stronger when used by a Mewtwo (assuming no EVs or nature affecting attack or special attack).
It isn't bad, it's just outclassed :P Not worth using.
Completely agree with JirachiCelebiMew in that using this set sucks compared to a special attack set.
Besides, its not like it doesn't have calm mind or anything
2 votes

Mewtwo @ Life Orb
Ability: Unnerve
EVs: 4 HP / 252 SpA / 252 Spe
Timid Nature
IVs: 0 Atk
- Psystrike
- Aura Sphere
- Calm Mind
- Shadow Ball

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1 vote

Double/Triple Battle

Mewtwo @ Life Orb
Ability: Pressure
EVs: 4 HP / 252 SpA / 252 Spd
Timid Nature
- Psystrike
- Blizzard
- Aura Sphere
- Charge Beam

There is a reason why Mewtwo is the fourth most powerful Pokemon (after Kyogre, Arceus, and Lugia). Mewtwo is simply amazing. Psystrike is incredibly powerful STAB. Blizzard hits multiple foes. Aura Sphere can hit any foe in a Triple Battle. Charge Beam can be used to finish off (which is actually a large amount of health remaining for some Pokemon, 407 Life Orb boosted Special Attack after all) a foe and possibly gain a Special Attack boost. Which means the end of all life as we know it.

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Old comment deleted. I'm an idiot. Even counting Meta, I wouldn't count Lugia as stronger than Mewtwo. Two totally different roles.
1 vote

Mewtwo @ Life Orb
Ability: Pressure
EVs: 4 Atk / 252 SpA / 252 Spe
Hasty Nature
- Psychic
- Recover
- Iron Tail
- Aura Sphere

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If your gonna ask about the "Pichu" Part
Make it bolded and then make a bunch of
spaces it cannot change back.
EVs?? Nature??
I'm not Gonna add that...
1 vote

enter image description here

The Best Special Sweeper in Town

Mewtwo @ Mewtwonite Y
Ability: Pressure / Unnerve --> Insomnia
Modest Nature
EVs: 252 SpA / 252 Spe / 4 HP
- Psystrike
- Aura Sphere
- Ice Beam / Thunderbolt / Flamethrower
- Calm Mind

This whole moveset is self-explanatory.

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1 vote

Its Toondude, back again with another answer over a response to a popular legendary.
Last time, I had responded over a solution to Thundurus, who hopefully wasn't a failure for the time being, but I decided to do something different...
Something Past-Like...
So, I present to you:

Gen 1 Mewtwo!

Why?: I got so lazy, and now that i've gotten used to the likes of Project 64 "Transfer Paks," I wanted to give this a try, so why don't we travel back when Mewtwo was once King of Gen 1.

Moves:
- Psychic - This move is already standard and one of the broken resourses Mewtwo had potential of back then, as Psychic Types pretty much ruled the throne, so Mewtwo had had access to it as a STAB move, as they existed in Generation 1.

  • Substitute, Ice Beam, Blizzard, Thunderbolt - This is quite a long explanation between useful resourses, but Substitute, which became decently viable against your friends in Pokemon Stadium had to get a mention here, aside from the Amnesia combo you can recieve to bulk up Mewtwo. If you do not want to, however, Ice Beam and Blizzard make viable coverage moves, especially with Blizzards buffed Accuracy back then (90%). If that is not the case aswell, Thunderbolt is yet another viable coverage move, especially it had more "Powerpoints" than Ice Beam.

  • Amnesia, Ice Beam, Blizzard, Thunderbolt - The same 3 coverage moves can still be placed to have Mewtwo act as an "All-Out Special Attacker," but if you wish for more variety, Amnesia placed with Psychic and another coverage move works very well, as it is the most broken move back then, especially before the Special Split.

  • Recover, Rest - This one is an obvious choice in final selections, and Mewtwo is one of the more reliable Pokemon that can use Recover and simply dust off any HP it takes. If thats not the case, Rest does trade off a 2-Turn Sleep Status and, since its Generation 1, the ability to not attack in return for any Status Removals and HP Recovery.

Counters:
There are limited Counters, but these are not limited to:
Thunder Wave: Electrode is viable with this move, and, being the fastest Pokemon in Gen 1, can easily bypass Mewtwo's Speed and Paralyze it before it even pulls off a Substitute to block it.
Hard Physical Hitters:: Pokemon that know such hard hitting moves like Explosion or Self Destruct can put a dent in Mewtwo's health as long as its left defenseless, but nonetheless Mewtwo can still pack a decent amount of Defense, live, and shrug it off with any recovery.
Special Walls: Chansey is one sort of Special Wall unless it goes up against Mewtwo for the worst in any other occasion.

In Conclusion:
Theres nothing else to say of Mewtwo in Generation 1. Tied with Mew, is none other the best Pokemon in Generation 1, especially with access to broken resourses Like Amnesia and Recover and Powerhoused moves like Blizzard and Psychic.

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1 vote

Rain Abuser

Mewtwo @ Damp Rock / Life Orb
Ability: Pressure
EVs: 252 SpA / 4 SpD / 252 Spe
Timid Nature
IVs: 0 Atk
- Rain Dance / Bubble Beam / Focus Blast
- Thunder
- Hurricane
- Psystrike / Psychic

really weird set

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Oh yeah this is big brain time
I was actually gonna do that!
I was wondering why you had 70 percent accurate moves in this set and then I remembered the accuracy thing in the rain
1 vote

Mewtwo, lend us your power!!!
Mewtwo
Gen VIII
Mewtwo @ Life Orb
Ability: Pressure
EVs: 4 HP / 252 SpA / 252 Spe
Modest Nature
- Psychic / Psystrike
- Shadow Ball
- Aura Sphere
- Nasty Plot / Calm Mind

Psychic and Psystrike are both STAB, it depends if you want to hit Pokemon with physical or special damage.
Shadow Ball is for coverage against Ghost types.
Aura Sphere is for coverage against Dark and Steel types, and also has infinite accuracy.
Both Nasty Plot and Calm Mind boost Mewtwo's already spectacular Special Attack.

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0 votes


Mewtwo @ Shell Bell
Ability: Pressure
Timid Nature
EVs: 252 SpA / 252 Spe / 4 HP
- Psystrike
- Aura Sphere
- Shadow Ball / Calm Mind
- Flamethrower / Ice Beam

Psystrike is a little bit better than Psychic, but Psychic has a chance to decrease the opponent's Special Defense.
Aura Sphere for coverage. This attack never misses!
Shadow Ball again for coverage and may decrease opponent's Special Defense. That's why I don't recommend Psychic on this Pokemon. Calm Mind increases Special Attack and Special Defense.
Flamethrower and Ice Beam for more type coverage!

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Shell Bell isn't good. If you must heal, use Leftovers.
0 votes

Ah, Mewtwo the original BAMF Pokemon.

Singles:

Mewtwo @ Choice Specs / Wise Glasses / Expert Belt
Ability: Pressure
Modest Nature
EVs: 252 SpA / 252 Spe / 4 HP
- Psychic
- Aura Sphere
- Ice Beam / Thunderbolt / Flamethrower
- Calm Mind

Doubles:

Mewtwo @ Choice Specs / Wise Glasses / Expert Belt
Ability: Pressure
Modest Nature
EVs: 252 SpA / 252 Spe / 4 HP
- Psychic
- Aura Sphere
- Thunderbolt
- Flamethrower

Pairing this with a Pokemon like Feraligatr will let you hit almost every Pokemon super effectively.

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Correction: you will do double damage to all except ones like Elektross, Sableye, and Spiritomb.
True Unbreakable. But while Elektross and Spiritomb can be very troublesome oppenents, Elektross' pre-evolution froms aren't very difficult and Sableye's stats are bad enough that an advantage is hardly necessary.
You're right. I overlooked that a bit.
Wise Glasses are awful, and Expert Belt is very niche.
They might be trying to fake a choice specs
0 votes

Suicide Lead Mewtwo

Mewtwo @ Light Clay
Trait: Pressure
Hasty Nature (+ Spd, - Def)
EVs: 128 Atk / 128 SAtk / 252 Spe
Moves:
- Taunt
- Selfdestruct
- Reflect
- Light Screen

Simple. Mewtwo leads off with a very fast Taunt, one of the fastest in the game, then proceeds to set up. Darkrai can't Void after the Taunt, and Mewtwo can SelfDestruct out so that other teammates can abuse its screens before they wear off.

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How does it learn Selfdestruct?
Yeah, I checked all the moves it can learn in heartgold/soulsilver and black/white, plus tms. I can't see how.
Why train Special Attack?  This set doesn't have any use for that.
this set is kinda REALLY REALLY BAD
0 votes

Mewtwo @ Mewtwonite X
Ability: Pressure / Steadfast
Serious Nature
EVs: 152 HP / 152 Atk / 100 SpA / 100 Spe
- Psycho Cut (STAB, good power and higher crit rate)
- Aura Sphere (Good power, amazing accuracy, STAB when Mega Evolved, weakness coverage)
- Stone Edge (Great power, higher crit rate, weakness coverage)
- Shadow Ball / Poison Jab (Covers a weakness in both forms, good power and secondary effect/covers Fairy weakness during Mega Evolution, good chance to poison)

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0 votes

"I am Mewtwo, the world's most powerful Pokémon." –Mewtwo

enter image description here
I hope this quote inspired you to give your Mewtwo a great moveset as much as it did me.

Okay, so I have 3 seperate movesets: two for each Mega Evo and one if you're playing in Gen 5 or earlier.



Mega Mewtwo X @ Mewtwonite X
Mega Mewtwo X
Ability: Pressure --> Steadfast
Jolly Nature
EVs: 252 Atk / 252 Spd / 4 HP
- Brick Break
- Psycho Cut
- Earthquake
- Poison Jab

The first two are STAB moves that have good coverage by themselves. Earthquake has great power and coverage, and Poison Jab just became great for killing Fairies.



Mega Mewtwo Y @ Mewtwonite Y
Mega Mewtwo Y
Ability: Pressure --> Insomnia
Timid Nature
EVs: 252 SpA / 160 Spd / 100 HP
- Psystrike
- Aura Sphere
- Ice Beam
- Thunderbolt

Psystrike is a STAB move that does physical damage (nice since Pokémon that are weak to Psychic often have good Special Defense). Aura Sphere is good for Dark-types, as well as many others. And of course, Mewtwo gets the BoltBeam combo.



Mewtwo @ Expert Belt
Mewtwo
Ability: Pressure
Timid Nature
EVs: 252 SpA / 252 Spd / 4 HP
- Psystrike
- Aura Sphere
- Ice Beam
- Thunderbolt

Since both Mewtwo and Mega Mewtwo Y are special attackers, they have the same moveset. Note that the held item and EVs are different, though.



So there you go. Mewtwo is a great competitive Pokémon, as its Mega form is the most powerful in the entire game. I hope you liked it, and if you did or have anything to say, feel free to leave a vote/comment.
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how are 3 of Mewtwo X's stats maxed out??
Sorry bout that…
I'd give Mewtwo X drain punch so It can recover and zen headbutt instead of psycho cut
MOST POWERFUL MEGA????? Um, Mega Rayquaza is the most powerful mega.
0 votes

Mewtwo @ Mewtwonite Y
Ability: Pressure -> Insomnia
EVs: 252 SpA / 4 HP / 252 Spe
Timid Nature
- Psystrike
- Ice Beam / Blizzard
- Fire Blast / Shadow Ball / Thunderbolt
- Calm Mind

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0 votes

Mewtwo @ Mewtwonite X
Ability: Pressure --> Steadfast
Jolly Nature
EVs: 252 Atk / 252 Spe / 4 HP
- Bulk Up
- Drain Punch / Low Kick
- Zen Headbutt / Psycho Cut
- Stone Edge / Rock Slide / Poison Jab / Ice Beam

Bulk Up boosts Attack and Defence by one stage.
Drain Punch is STAB and recovers health. Low Kick is the alternative option as many Pokemon in the Uber tier weigh alot. Hits Rock, Steel, Normal, Dark and Ice types.
Zen Headbutt is the second STAB move and hits hard and can flinch. Psycho Cut is a slightly weaker option that has a high crit ratio and is more accurate. Hits Fighting and Poison types.
Stone Edge or Rock Slide are used to hit Flying types, mainly Ho-Oh and Lugia. Poison Jab is solely for hitting Fairy types hard. Ice Beam can be used to hit Dragon, Ground and some Flying types harder than the other moves.

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0 votes

Mewtwo @ Mewtwonite Y
Ability: Pressure --> Insomnia
Timid Nature
EVs: 252 SpA / 252 Spe / 4 SpD
- Psystrike
- Focus Blast / Aura Sphere
- Ice Beam
- Calm Mind / Shadow Ball / Recover

Psystrike is STAB and hits incredibly hard, especially on Pokemon that have a low physical defence stat. Hits Fighting and Poison types.
Focus Blast is for coverage and hits very hard. Aura Sphere is the weaker option but it never misses. Hits Steel, Normal, Dark, Rock and Ice types.
Ice Beam has great coverage alongside the two mentioned moves above and provides important coverage. Hits Dragon, Grass, Flying and Ground types.
Calm Mind is to boost its already high Special Attack and Special Defence to even higher levels. Shadow Ball can be used over it to hit Ghost and Psychic types. Recover is an option to restore health as Mega Mewtwo Y does force a lot of switches.

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You can run Shadow Ball over Ice Beam, I've found.
Ah ok, I'll try it out on PO sometime soon.
Aura Sphere is more reliable than Focus Blast
0 votes

Mewtwo X
Mewtwo @ Mewtwonite X
Ability: Pressure --> Steadfast
Nature: Jolly / Adamant
EVs: 252 Atk / 252 Spd / 4 HP
- Drain Punch
- Psycho Cut / Zen Headbutt
- Recover
- Ice Punch / Thunder Punch / Fire Punch

Mewtwo Y
Mewtwo @ Mewtwonite Y
Ability: Pressure --> Insomnia
Nature: Modest / Timid
EVs: 252 SpA / 252 Spd / 4 HP
- Aura Sphere
- Psystrike
- Recover
- Thunderbolt / Ice Beam / Flamethrower

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I love the movesets, but for mewtwo x, if you have Drain Punch wasting a move slot on recover is kind of dumb.